LÍNEA: QUÍMICA BIOORGÁNICA Y BIOTECNOLOGÍA 

 

DEFENSA DE TESIS

2.-"Biocatálisis para la diversificación química de aceites esenciales"

Doctorando: Farmacéutico Francisco Miguel Cecati
Dirección: Dra. Marcela Kurina-Sanz
Codirección: Dr. Carlos Ardanaz
Fecha de Defensa: 24 de mayo de 2019
Resumen: Este trabajo se ha orientado al desarrollo de herramientas para la valorización de recursos naturales renovables, accesibles y de bajo costo mediante tecnologías innovadoras y sustentables. Dentro de la complejidad del metaboloma que comparten una especie vegetal y sus microorganismos asociados, se ha abordado el estudio de los compuestos orgánicos volátiles (COVs) producidos por Eupatorium buniifolium y sus cepas fúngicas endófitas. Se han elegido como principales biotecnologías a las biotransformaciones y a las fermentaciones mediadas por hongos endófitos para acceder a bioproductos diversos, de potencial aplicación y aceptados por el mercado actual.

 

PRODUCCIÓN CIENTÍFICA RECIENTE

 

-“Broadening the repertoire of microbial aldo-ketoreductases: cloning and characterization of AKR3B4 from RhodotorulamucilaginosaLSL strain” Anello AL, Aguilera L, Kurina-Sanz M, JuriAyub M, Mascotti ML*. Enzyme Microb. Tech. 2020, 132, 109415.https://doi.org/10.1016/j.enzmictec.2019.109415.

-“Preparation of chiral β-hydroxytriazoles in one-pot chemoenzymatic bioprocesses catalyzed by Rhodotorulamucilaginosa” Aguirre-Pranzoni C, Tosso RD, Bisogno FR, Kurina-Sanz M*, Orden AA*. Process Biochem. 2019,147, 114-117.https://doi.org/10.1016/j.procbio.2018.12.011.

-“Thiol-free chemoenzymatic synthesis of β-ketosulfides” Heredia AA, López-Vidal MG, Kurina-Sanz M, Bisogno FR*, Peñéñory AB., Beilstein J. Org. Chem. 2019, 15, 378–38 https://doi:10.3762/bjoc.15.34.

-“N-acetylneuraminic acid aldolase-catalyzed synthesis of acyclic nucleoside analogues carring a 4-hydroxy-2-oxoacid moiety”Nigro M, Palazzolo M, Colasurdo D, Iribarren A, Lewkowicz L. Catal.Commun., 2019, 121, 73-77. DOI: 10.1016/j.catcom.2018.12.013

-“From agro-waste to tool: biotechnological characterization and application of Ganodermalucidum E47 laccase in dye decolorization”Palazzolo MA, Postemsky PD, Kurina-Sanz M. 3Biotech, 2019, 9, 213. https://doi.org/10.1007/s13205-019-1744-2.

-“Trypanocidal natural productproducedbyendophyticfungithroughco-culturing” Santos do Nascimento J, Moura Silva F, Magallanes-Noguera CA, Kurina-Sanz M, Gonçalves dos Santos E, Santana Caldas I, HortolanLuiz JH, de Oliveira Silva E. Folia Microbiologica. 2019. 65(2), 323-328 https://doi.org/10.1007/s12223-019-00727-x.

-“Preparation of lignosulfonate-based carbon foams by pyrolysis and its use in the microencapsulation of a Phase Change Material”Palazzolo MA,Dourges M-A, Magueresse A, Glouannec P, Maheo L, Deleuze H. ACS Sustain. Chem. Eng. 2018, 6 (2), 2453-2461. DOI : 10.1021/acssuschemeng.7b03900.

-“Ecofriendly chemical diversification of Eupatorium buniifolium essential oil by endophytic fungi”Cecati FM; Magallanes-Noguera C; Tonn CE; Ardanaz CE; Kurina-Sanz M*, Process Biochem. 2018, 64, 93-102,https://doi.org/10.1016/j.procbio.2017.09.028.

-“In vivo photoinduced [4+2] dimerization of a neo-clerodanediterpene in Baccharisflabellata. ROS and RNS scavenging abilities”Funes MD; Tonn CE; Kurina-Sanz M*, J. Photochem. Photobiol. B, Biol. 2018, 186, 137-143, https://doi.org/10.1016/j.jphotobiol.2018.06.020.

-“Assessment of the Insecticidal Potential of the Eupatorium buniifolium essential oil against Triatomainfestans (Hemiptera: Reduviidae). A chiral recognition approach” Guerreiro AC, Cecati FM, Ardanaz CE, Donadel OJ, Tonn CE, Sosa ME.Neotropical Entomology. 2018, 64, 93-102.

-“Plant tissue cultures as sources of new ene- and ketoreductase activities” Magallanes-Noguera C; Cecati FM; Mascotti ML, Reta GF; Agostini E; Orden AA*; Kurina-Sanz M*, J. Biotechnol. 2017, 28, 251, 14-20,DOI:10.1016/j.jbiotec.2017.03.023

-“Treatment of endosulfan contaminated water with in vitro plant cell cultures” Lucero PA, Ferrari MM, Orden AA, Cañas I, Nassetta M, Kurina-Sanz, M*. J Hazard. Mater.2016 15; 305: 149-55, https//:doi10.1016/j.jhazmat.2015.11.027.

-“Biotechnological tools to improve bioremediation of phenol by Acinetobacter sp. RTE1.4.”. Paisio CE, Talano M, González PS, Magallanes-Noguera C, Kurina-Sanz M, Agostini E. Environ. Technol., 2016 (18):2379-90. DOI:10.1080/09593330.2016.1150352.

-“Biotransformation of dehydro-epi-androsterone by Aspergillusparasiticus: metabolic evidences of BVMO activity”Mascotti ML; Palazzolo MA; Bisogno FR; Kurina-Sanz M. Steroids,2016, 109:44-9. http://dx.doi.org/10.1016/j.steroids.2016.03.018.

-“Microbial utilization of lignin: available biotechnologies for its degradation and valorization" Palazzolo MA &Kurina-Sanz M. World J MicrobiolBiotechnol.2016, 26; 32(10):173. http://dx.doi.org/10.1007/s11274-016-2128-y

-“Lyophilized Rhodotorula yeast as all-in-one redox biocatalyst: Access to enantiopure building blocks by simple chemoenzymatic one-pot procedures” C Aguirre-Pranzoni, FR Bisogno, AA Orden, MKurinaSanz*. J. Mol. Catal. B: Enzym.2015, 114, 19-24. https://doi.org/10.1016/j.molcatb.2014.07.011.

-“A study of Raphanussativus and itsendophytesas  carbonylgroupbioreducingagents” Rodriguez, P; Magallanes-Noguera, C; Menendez, P; Orden, AA, Gonzalez, D; Kurina-Sanz, M; Rodriguez-Giordano, S.Biocatalysis&Biotransformation, 2015, 33(2): 121–129.http://dx.doi.org/10.3109/10242422.2015.1053471

-“Self-sufficient redox biotransformation of lignin-related benzoic acids with Aspergillusflavus” Palazzolo MA, Mascotti ML, Lewkowicz ES, Kurina-Sanz M*. J. Ind. Microbiol. Biotechnol.,2015, 42 (12):15819. doi: 10.1007/s10295-015-1696-4.

 

  1. "A chemoenzymatic synthesis of acycilc nucleoside analogues using rabbit muscle aldolase". Palazzolo, M.A.; Nigro, M.J.; Irribarren, A.M.; Lewkowcz, E.S., European journal of organic chemistry. Weinheim: WILEY-V C H VERLAG GMBH, 2016. p.921-924. ISSN 1434-193X.
  1. Broadening the repertoire of microbial aldo-keto reductases: cloning and characterization of AKR3B4 from Rhodotorula mucilaginosa LSL strain. Anello AL, Aguilera L, Kurina-Sanz M, Juri Ayub M, Mascotti ML*.Enzyme and Microbial Technology 2020, 132, 109415. https://doi.org/10.1016/j.enzmictec.2019.109415